Squeak has amazing sound capabilities, from playing MIDI files (via an internal synthesizer or via a MIDI-compatible external synthesizer), to generating multiple instruments with multiple voices at once (see AbstractSound and FMSound, especially the class methods), and even recording sound and playing a wide variety of sampled sound files (including WAV, AIFF, and u-law files).
To write one buffer of sound, make an instance of SampledSound and then tell it to #play. To stream sound, you will need to do a little more programming.